Ribosomal protein L11



Ribosomal protein L11 (RPL11) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 23S RRNA from the large subunit. In Archaea the protein is named L11P. The images at the left and at the right correspond to one representative RPL11, i.e. the NMR structure of Ribosomal protein L11 from Thermus thermophilus (2klm).

RPL11
2klm – TtRPL11 - Thermus thermophilus – SAXS

2e34 – TtRPL11 – RDC

2e35 – TtRPL11 – RG

2e36 – TtRPL11 – SANS

2h8w – TtRPL11 - NMR

1aci, 1foy, 1fow, 1fox, 2fow – GsRPL11 C-terminal – Geobacillus stearothermophilus – NMR

1y39, 1qa6 - GsRPL11 C-terminal+ 23S RRNA fragment

2k3f – TmRPL11 – Thermotoga maritima – NMR

1r2w, 1r2x, 1mms - TmRPL11 +23S RRNA fragment

1hc8 - RPL11 C-terminal+23S RRNA fragment – Bacillus stearothermophilus

1jqt – EcRPL11 – Cryo-EM - Escherichia coli

L11 in 50S subunit+RNA
2x9s, 2x9u, 2wrj, 2wrl, 2wro, 2wrr, 2wh2, 2wh4, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3i8i, 3f1f, 3f1h, 2b66, 2b9n, 2b9p, 1giy, 2xqe - TtRPL11 in 50S subunit+5S RRNA+23S RRNA

3fin - TtRPL11 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

2wwq – EcRPL11 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA

3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0 - EcRPL11 in 50S subunit+5S RRNA+23S RRNA

3fik, 2gya, 2gyc, 1p85, 1p86 - EcRPL11 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

3kcr - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase

3bbo - RPL11 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach

2zjq, 2zjr, 1nkw - DrRPL11 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans

2qa4, 3cc2, 1s72 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA – Haloarcula marismortui

3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant)

1yj9 - HmRPL11P in 50S subunit (mutant)+5S RRNA+23S RRNA

3cma, 3cme, 1vq8, 1vq9 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA+CCA+CCA-Phe-CAP-BIO

1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp – HmRPL11P in 50S subunit+5S RRNA+23S RRNA+transition state analog

1vq6, 1vqk, 1vqn – HmRPL11P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin

1vqo – HmRPL11P in 50S subunit+5S RRNA+23S RRNA+ CCPMN

3iy9 – RPL11 in 50S subunit – Leishmania taretolae

2ftc – RPL11 in 50S subunit+5S RRNA+23S RRNA – bovine - Cryo_EM

L11 in 50S subunit + antibiotics
3dll - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor

2zjp - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide

3cf5 - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton

1xbp - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin

1sm1 - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin

1nwx - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773

1nwy - DrRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin

2qam, 2qao, 2qoz, 2qp1 - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+neomycin

2qba, 2qbc - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+gentamicin

3ofc – EcRPL11 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol

3ofz – EcRPL11 in 50S subunit+5S RRNA+23S RRNA+clindamycin

3ofq, 3ofr – EcRP11 in 50S subunit+5S RRNA+23S RRNA+erythromycin

1vt2, 3orb – EcRPL11 in 50S subunit+5S RRNA+23S RRNA+CEM-101

2jq7 – TmRPL11+23S RRNA binding domain+thiostrepton – NMR

1oln - TmRPL11+23S RRNA binding domain+thiostrepton – Cryo-EM

3i55 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + mycalamide

3i56 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + troleandomycin

3g4s - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + tiamulin

3g4e - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + homoharringtonine

3g71 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + bruceantin

2qex - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + negamycin

3cc4 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + anisomycin

3cd6 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant) + puromycin

1yhq - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant) + azithromycin

1yi2 - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant) + erythromycin

1yij - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant) + telithromycin

1yjn - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant) + clidamycin

1yjw - HmRPL11P in 50S subunit+5S RRNA+23S RRNA (mutant) + quinupristin

2otj - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + 13-deoxytedanolide

2otl - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + girodazole

1yit - HmRPL11P in 50S subunit+5S RRNA+23S RRNA + virginiamycin

L11 in 60S subunit
3jyw - RPL11 in 60S subunit – Thermomyces lanuginosus – Cryo-EM

1s1i - yRPL11 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

L11 in large + small ribosomal subunit
1ml5 - EcRPL11 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM

2zkr - RPL11 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM – dog

L11 in 50S subunit + ribosome releasing factor (RRF)
2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+RRF

2rdo - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM

L11 in 50S subunit + elongation factor (EF)
3ep2, 3eq3, 3eq4 – EcRPL11+RPS12+tRNA+16S RRNA fragments+23S RRNA fragments+EF-TU – Cryo-EM

2bcw – TmRPL11 N-terminal+EcRPL12 C-terminal +TtEF-G – Cryo-EM

1mj1 – EcRPL11+RPS12+RPS13+ 23S RRNA fragments+Phe-tRNA+EF-TU – Cryo-EM

1jqm, 1jqs - EcRPL11 +EF-G – Cryo-EM

L11 in 50S subunit + various proteins
2vhm - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix

2j28 - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM

1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL11 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc

3deg – EcRPL11+RPS12+A-site tRNA+P-site tRNA+16S RRNA fragments+23S RRNA fragments+GTP-binding protein LEPA – Cryo_EM

3cjs – TtRPL11 N-terminal+RPL11 methyltransferase N-terminal

3cjt - TtRPL11+RPL11 methyltransferase

L11 in part of 50S subunit
1c04 – HmRPL11P+RPL2+RPL6+RPL14+23S RRNA fragment

1eg0 – EcRPL11+RPL1+RPL6+RPS4+RPS5+RPS6+RPS7+RPS8+RPS15+RPS17+RPS20+fMet-tRNA+23S RRNA fragment – Cryo-EM

487d – RPL11+RPL1+RPL2+RPL9+RPL6+RPL14+RPL25 – Cryo-EM

1pn7 – TmRPL11+TtRPS12+P-site tRNA – Cryo-EM

1pn8 - TmRPL11+TtRPS12+E-site tRNA – Cryo-EM

1mvr - EcRPL11+RPS12+ mRNA triplet+16S RRNA fragments+23S RRNA fragments